Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone-Reference-Cited by-同舟云学术

Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone

Published:2020-10-21 Issue:21 Volume:63 Page:13064-13075
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Andring Jacob T.¹^ORCID,Fouch Mallorie²,Akocak Suleyman²,Angeli Andrea³^ORCID,Supuran Claudiu T.³^ORCID,Ilies Marc A.²^ORCID,McKenna Robert¹

Affiliation:

1. Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida 32610, United States

2. Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, Pennsylvania 19140, United States

3. NEUROFARBA Department, Pharmaceutical Sciences Section, Universita degli Studi di Firenze, Polo Scientifico, Via Ugo Schiff no. 6, 50019 Sesto Fiorentino, Florence, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01390

Reference83 articles.

1. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

2. Targeting HIF-1 for cancer therapy

3. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

4. Interfering with pH regulation in tumours as a therapeutic strategy

5. Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

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