Synthesis and Structure–Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases-Reference-Cited by-同舟云学术

Synthesis and Structure–Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases

Published:2020-12-01 Issue:23 Volume:63 Page:14885-14904
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Han Wooseok¹²^ORCID,Ding Yu¹³,Chen Zheng¹⁴,Langowski John L.¹⁵,Bellamacina Cornelia¹⁶,Rico Alice¹⁷,Nishiguchi Gisele A.¹⁸,Lan Jiong¹⁹,Atallah Gordana¹¹⁰,Lindvall Mika¹¹¹,Lin Song¹¹²,Zang Richard¹¹³,Feucht Paul¹,Zavorotinskaya Tatiana¹¹⁴,Dai Yumin¹¹⁵,Garcia Pablo¹¹⁶,Burger Matthew T.¹¹⁷

Affiliation:

1. Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States

2. Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States

3. BeiGene, Ltd., San Mateo, California 94403, United States

4. Boston Analytical, Salem, New Hampshire 03079, United States

5. Kite, a Gilead Company, Emeryville, California 94608, United States

6. Crystallographic Consulting, Berkeley, California 94704, United States

7. Exelixis, Alameda, California 94502, United States

8. St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, United States

9. Genfleet Therapeutics, Inc., Pudong District, Shanghai 201203, China

10. Pharmacyclics, an AbbVie Company, Sunnyvale, California 94085, United States

11. Recursion Pharmaceuticals, Salt Lake City, Utah 84101, United States

12. Astex Pharmaceuticals Inc., Pleasanton, California 94588, United States

13. Global Blood Therapeutics, South San Francisco, California 94080, United States

14. ORIC Pharmaceuticals, South San Francisco, California 94080, United States

15. Bristol Myers Squibb, Redwood City, California 94158, United States

16. Circle Pharma, Inc., South San Francisco, California 94080, United States

17. Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01279

Reference43 articles.

1. Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region

2. PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

3. Transgenic mice as a means to study synergism between oncogenes

4. For better or for worse: the role of Pim oncogenes in tumorigenesis

5. Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors

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