2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis

Author:

Codony Sandra1,Pujol Eugènia1,Pizarro Javier234,Feixas Ferran5,Valverde Elena1,Loza M. Isabel6,Brea José M.6,Saez Elena7,Oyarzabal Julen7ORCID,Pineda-Lucena Antonio7,Pérez Belén8,Pérez Concepción9,Rodríguez-Franco María Isabel9ORCID,Leiva Rosana10,Osuna Sílvia511ORCID,Morisseau Christophe12,Hammock Bruce D.12ORCID,Vázquez-Carrera Manuel234,Vázquez Santiago1ORCID

Affiliation:

1. Laboratori de Quı́mica Farmacèutica (Unitat Associada al CSIC), Departament de Farmacologia, Toxicologia i Quı́mica Terapèutica, Facultat de Farmàcia i Ciències de l’Alimentació, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain

2. Pharmacology, Departament de Farmacologia, Toxicologia i Quı́mica Terapèutica, Facultat de Farmàcia i Ciències de l’Alimentació, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain

3. Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029 Madrid, Spain

4. Pediatric Research Institute-Hospital Sant Joan de Déu, 08950 Esplugues de Llobregat, Spain

5. CompBioLab Group, Departament de Quı́mica and Institut de Quı́mica Computacional i Catàlisi (IQCC), Universitat de Girona, C/ Maria Aurèlia Capmany 69, 17003 Girona, Spain

6. Drug Screening Platform/Biofarma Research Group, CIMUS Research Center, University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain

7. Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain

8. Department of Pharmacology, Therapeutics and Toxicology, Institute of Neurosciences, Autonomous University of Barcelona, Bellaterra, 08193 Barcelona, Spain

9. Institute of Medicinal Chemistry, Spanish National Research Council (CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain

10. Laboratori de Quı́mica Farmacèutica (Unitat Associada al CSIC), Universitat de Barcelona, 08028 Barcelona, Spain

11. Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain

12. Department of Entomology and Nematology and Comprehensive Cancer Center, University of California, Davis, Davis, California 95616, United States

Funder

National Institute of Environmental Health Sciences

Fundaci? Bosch i Gimpera

National Institute of Neurological Disorders and Stroke

Ministerio de Econom?a, Industria y Competitividad, Gobierno de Espa?a

National Institute of Diabetes and Digestive and Kidney Diseases

European Regional Development Fund

Xunta de Galicia

Generalitat de Catalunya

?la Caixa? Foundation

H2020 Marie Sklodowska-Curie Actions

H2020 European Institute of Innovation and Technology

Ministerio de Educaci?n, Cultura y Deporte

H2020 European Research Council

Universitat de Barcelona

Fundaci?n Fuentes Dutor

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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