Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis-Reference-Cited by-同舟云学术

Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis

Published:2023-06-19 Issue:13 Volume:66 Page:9201-9222
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Musella Simona¹,D’Avino Danilo²^ORCID,Peltner Lukas Klaus³,Di Sarno Veronica¹,Cerqua Ida²,Merciai Fabrizio¹,Vestuto Vincenzo¹,Ciaglia Tania¹,Smaldone Gerardina¹,Di Matteo Francesca¹,Di Micco Simone⁴^ORCID,Napolitano Valeria¹,Bifulco Giuseppe¹^ORCID,Pepe Giacomo¹^ORCID,Sommella Eduardo Maria¹,Basilicata Manuela Giovanna¹,Aquino Giovanna¹⁵,Gomez-Monterrey Isabel M.²^ORCID,Campiglia Pietro¹⁴^ORCID,Ostacolo Carmine¹^ORCID,Roviezzo Fiorentina²,Werz Oliver³^ORCID,Rossi Antonietta²,Bertamino Alessia¹^ORCID

Affiliation:

1. Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy

2. Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy

3. Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University, Philosophenweg 14, D-07743 Jena, Germany

4. European Biomedical Research Institute (EBRIS), Via S. De Renzi 50, 84125 Salerno, Italy

5. PhD Program in Drug Discovery and Development, University of Salerno, 84084 Fisciano, SA, Italy

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Associazione Italiana per la Ricerca sul Cancro

Università degli Studi di Napoli Federico II

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00831

Reference57 articles.

1. Epoxygenase Pathways of Arachidonic Acid Metabolism

2. Soluble epoxide hydrolase is a therapeutic target for acute inflammation

3. Soluble epoxide hydrolase inhibitor, TPPU, increases regulatory T cells pathway in an arthritis model

4. Soluble Epoxide Hydrolase in Atherosclerosis

5. Small Molecule Soluble Epoxide Hydrolase Inhibitors in Multitarget and Combination Therapies for Inflammation and Cancer

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