Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii-Reference-Cited by-同舟云学术

Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii

Published:2020-12-11 Issue:24 Volume:63 Page:15802-15820
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Davies David T.¹^ORCID,Leiris Simon¹,Zalacain Magdalena¹,Sprynski Nicolas¹^ORCID,Castandet Jérôme¹,Bousquet Justine¹,Lozano Clarisse¹,Llanos Agustina¹,Alibaud Laethitia¹,Vasa Srinivas²,Pattipati Ramesh²^ORCID,Valige Ravindar²,Kummari Bhaskar²,Pothukanuri Srinivasu²^ORCID,De Piano Cyntia³,Morrissey Ian³,Holden Kirsty⁴,Warn Peter⁴,Marcoccia Francesca⁵,Benvenuti Manuela⁶^ORCID,Pozzi Cecilia⁶^ORCID,Tassone Giusy⁶^ORCID,Mangani Stefano⁶^ORCID,Docquier Jean-Denis⁵^ORCID,Pallin David⁷^ORCID,Elliot Richard⁷,Lemonnier Marc¹^ORCID,Everett Martin¹^ORCID

Affiliation:

1. Antabio SAS, 436 rue Pierre et Marie Curie, 31670 Labège, France

2. GVK Biosciences Pvt. Ltd., Survey No. 125 and 126, IDA, Mallapur, Hyderabad, Telangana 500 076, India

3. International Health Management Associates (IHMA), Rte. De I’Ile-au-Bois 1A, 1870 Monthey, Switzerland

4. Evotec (UK) Ltd., Block 23, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.

5. Dipartimento di Biotecnologie Mediche, University of Siena, Viale Bracci 16, Siena 53100, Italy

6. Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena, Via Aldo Moro 2, Siena 53100, Italy

7. Charles River Laboratories, 8-9 The Spire Green Centre, Harlow, Essex CM19 5TR, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01535

Reference45 articles.

1. O’Neill, J. Review on Antimicrobial Resistance, Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations, 2016. For this seminal review of antibacterial resistance, see https://amr-review.org/home.html (accessed May 5, 2020).

2. Updated Functional Classification of β-Lactamases

3. The combination of clavulanic acid and amoxycillin (AugmentinR) in the treatment of patients infected with penicillinase producing gonococci

4. Extended-Spectrum β-Lactamases: a Clinical Update

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