Medicinal Chemistry Optimization of a Diaminopurine Chemotype: Toward a Lead for Trypanosoma brucei Inhibitors-Reference-Cited by-同舟云学术

Medicinal Chemistry Optimization of a Diaminopurine Chemotype: Toward a Lead for Trypanosoma brucei Inhibitors

Published:2020-07-30 Issue:17 Volume:63 Page:9912-9927
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Singh Baljinder¹^ORCID,Diaz-Gonzalez Rosario²,Ceballos-Perez Gloria²,Rojas-Barros Domingo I.²,Gunaganti Naresh¹,Gillingwater Kirsten³⁴,Martinez-Martinez Maria Santos⁵,Manzano Pilar⁵,Navarro Miguel²,Pollastri Michael P.¹^ORCID

Affiliation:

1. Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States

2. Instituto de Parasitología y Biomedicina “López-Neyra” Consejo Superior de Investigaciones Científicas (CSIC), Granada 18016, Spain

3. Parasite Chemotherapy Unit, Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland

4. University of Basel, Petersplatz 1, 4001 Basel, Switzerland

5. Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline, Tres Cantos 28760, Spain

Funder

National Institute of Allergy and Infectious Diseases

Tres Cantos Open Lab Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01017

Reference24 articles.

1. World Health Organization. Neglected Tropical Diseases. https://www.who.int/neglected_diseases/diseases/en/ (accessed May 13, 2019).

2. Drugs for Neglected Diseases Initiative: About Sleeping Sickness. https://www.dndi.org/diseases-projects/hat/ (accessed May 13, 2019).

3. Centers for Disease Control and Prevention. Parasites—African Trypanosomiasis. https://www.cdc.gov/parasites/sleepingsickness/epi.html (accessed April 7, 2020).

4. WHO. Outlines Criteria to Assess Elimination of Sleeping Sickness. https://www.who.int/neglected_diseases/news/criteria-eliminate-sleeping-sickness/en/ (accessed May 27, 2020).

5. Drugs for Neglected Diseases Initiative: About Sleeping Sickness, Disease Background. https://www.dndi.org/diseases-projects/hat/hat-disease-background/ (accessed May 27, 2020).

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