Chemical Optimization of CBL0137 for Human African Trypanosomiasis Lead Drug Discovery-Reference-Cited by-同舟云学术

Chemical Optimization of CBL0137 for Human African Trypanosomiasis Lead Drug Discovery

Published:2023-01-25 Issue:3 Volume:66 Page:1972-1989
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Singh Baljinder¹^ORCID,Sharma Amrita²,Gunaganti Naresh¹,Rivers Mitch¹,Gadekar Pradip K.¹^ORCID,Greene Brady¹,Chichioco Michael¹,Sanz-Rodriguez Carlos E.³^ORCID,Fu Courtney¹,LeBlanc Catherine¹,Burchfield Erin¹,Sharif Nyle¹,Hoffman Benjamin³,Kumar Gaurav²,Purmal Andrei⁴,Mensa-Wilmot Kojo²³,Pollastri Michael P.¹^ORCID

Affiliation:

1. Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States

2. Department of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, Georgia 30144, United States

3. Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602, United States

4. Incuron Inc., Buffalo, New York 14203, United States

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01767

Reference22 articles.

1. NIH-NIAID. Neglected Tropical Diseases. https://www.niaid.nih.gov/research/neglected-tropical-diseases (accessed June 02, 2021).

2. WHO. Trypanosomiasis, Human African (Sleeping Sickness). https://www.who.int/news-room/fact-sheets/detail/trypanosomiasis-human-african-(sleeping-sickness) (accessed June 2, 2021).

3. Medicinal Chemistry Optimization of a Diaminopurine Chemotype: Toward a Lead for Trypanosoma brucei Inhibitors

4. Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis

5. Sarantopoulos, J. I. R.; Dowlati, A.; Ahluwalia, M. A Phase 1 Trial of CBL0137 in Patients With Metastatic or Unresectable Advanced Solid Neoplasm. ClinicalTrials.gov Identifier NCT01905228, 2020. https://clinicaltrials.gov/ct2/show/NCT01905228 (accessed August 22, 2022).

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