A γ-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli-Reference-Cited by-同舟云学术

A γ-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli

Published:2020-05-18 Issue:11 Volume:63 Page:5990-6002
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Goldberg Joel A.¹,Nguyen Ha²,Kumar Vijay²,Spencer Elizabeth J.³,Hoyer Denton³,Marshall Emma K.¹,Cmolik Anna¹,O’Shea Margaret¹,Marshall Steven H.¹,Hujer Andrea M.¹⁴,Hujer Kristine M.¹⁴,Rudin Susan D.¹⁴,Domitrovic T. Nicholas¹⁴,Bethel Christopher R.¹,Papp-Wallace Krisztina M.¹²⁴,Logan Latania K.⁵⁶,Perez Federico¹⁴⁷,Jacobs Michael R.⁴⁸,van Duin David⁹,Kreiswirth Barry M.¹⁰,Bonomo Robert A.¹²⁴⁷¹¹^ORCID,Plummer Mark S.³,van den Akker Focco²

Affiliation:

1. Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States

2. Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States

3. Yale Center for Molecular Discovery, West Haven, Connecticut 06516, United States

4. Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, United States

5. Department of Pediatrics, Rush University Medical Center, Rush Medical College, Chicago, Illinois 60612, United States

6. Cook County Health and Hospital Systems, Chicago, Illinois 60612, United States

7. Geriatric Research, Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States

8. Department of Pathology, University Hospitals Cleveland Medical Center, Division of Clinical Microbiology, Cleveland, Ohio 44106, United States

9. University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514, United States

10. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07601, United States

11. Departments of Pharmacology, Molecular Biology & Microbiology, and Proteomics & Bioinformatics, Case Western Reserve University, Cleveland, Ohio 44106, United States

Funder

U.S. Department of Veterans Affairs

National Institute of Allergy and Infectious Diseases

Connecticut Innovations

Office of Research and Development

Geriatric Research Education and Clinical Center

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00255

Reference41 articles.

1. a Ctrol and Prevention (2019) Antibiotic Resistance Threats in the United States, 2019 AR Threats Report https://www.cdc.gov/drugresistance/biggest-threats.html (accessed Mar 11, 2020)

2. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis

3. World Health Organization. Antimicrobial Resistance: Global Report on Surveillance, 2014. https://www.who.int/antimicrobial-resistance/publications/surveillancereport/en/ (accessed Mar 11, 2020).

4. The Epidemic of Antibiotic-Resistant Infections: A Call to Action for the Medical Community from the Infectious Diseases Society of America

5. Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

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