Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF-Reference-Cited by-同舟云学术

Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

Published:2015-05-20 Issue:4 Volume:59 Page:1642-1647
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bennett James¹²,Fedorov Oleg¹²,Tallant Cynthia¹²,Monteiro Octovia¹²,Meier Julia²,Gamble Vicky²,Savitsky Pavel¹²,Nunez-Alonso Graciela A¹²,Haendler Bernard³,Rogers Catherine¹²,Brennan Paul E.¹²,Müller Susanne¹²,Knapp Stefan¹²⁴

Affiliation:

1. The Structural Genomic Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, U.K.

2. Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Headington, Oxford OX3 7FZ, U.K.

3. Global Drug Discovery, Bayer Pharma AG, Müllerstrasse 178, D-13353 Berlin, Germany

4. Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9 D-60438 Frankfurt am Main, Germany

Funder

Bayer

Wellcome Trust

Structural Genomics Consortium, University of Oxford

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00458

Reference34 articles.

1. Bromodomains as therapeutic targets

2. Targeting bromodomains: epigenetic readers of lysine acetylation

3. Selective inhibition of BET bromodomains

4. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

5. BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

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