Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia-Reference-Cited by-同舟云学术

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Published:2011-10 Issue:7370 Volume:478 Page:529-533
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Dawson Mark A.,Prinjha Rab K.,Dittmann Antje,Giotopoulos George,Bantscheff Marcus,Chan Wai-In,Robson Samuel C.,Chung Chun-wa,Hopf Carsten,Savitski Mikhail M.,Huthmacher Carola,Gudgin Emma,Lugo Dave,Beinke Soren,Chapman Trevor D.,Roberts Emma J.,Soden Peter E.,Auger Kurt R.,Mirguet Olivier,Doehner Konstanze,Delwel Ruud,Burnett Alan K.,Jeffrey Phillip,Drewes Gerard,Lee Kevin,Huntly Brian J. P.,Kouzarides Tony

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature10509.pdf

Reference21 articles.

1. Krivtsov, A. V. & Armstrong, S. A. MLL translocations, histone modifications and leukaemia stem-cell development. Nature Rev. Cancer 7, 823–833 (2007)

2. Lin, C. et al. AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. Mol. Cell 37, 429–437 (2010)

3. Yokoyama, A., Lin, M., Naresh, A., Kitabayashi, I. & Cleary, M. L. A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer Cell 17, 198–212 (2010)

4. Milne, T. A. et al. Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis. Mol. Cell 38, 853–863 (2010)

5. Muntean, A. G. et al. The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis. Cancer Cell 17, 609–621 (2010)

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