A Pyrazolo[3,4-d]pyrimidin-4-amine Derivative Containing an Isoxazole Moiety Is a Selective and Potent Inhibitor of RET Gatekeeper Mutants-Reference-Cited by-同舟云学术

A Pyrazolo[3,4-d]pyrimidin-4-amine Derivative Containing an Isoxazole Moiety Is a Selective and Potent Inhibitor of RET Gatekeeper Mutants

Published:2015-12-22 Issue:1 Volume:59 Page:358-373
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yoon Hojong¹,Kwak Yeonui²,Choi Seunghye²,Cho Hanna²,Kim Nam Doo³,Sim Taebo¹²

Affiliation:

1. Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 136-791, Republic of Korea

2. KU-KIST Graduate School of Converging Science and Technology, Korea University, 145, Anam-ro, Seongbuk-gu, Seoul, 136-713, Republic of Korea

3. Daegu-Gyeongbuk Medical Innovation Foundation, 2387 dalgubeol-daero, Suseong-gu, Daegu 706-010, Republic of Korea

Funder

National Research Foundation of Korea

Korea Basic Science Institute

Korea Institute of Science and Technology

Korea University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01522

Reference37 articles.

1. Expression of theRET proto-oncogene in human Embryos

2. Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts

3. RET tyrosine kinase signaling in development and cancer

4. Critical and distinct roles for key RET tyrosine docking sites in renal development

5. RET PLCγ Phosphotyrosine Binding Domain Regulates Ca2+ Signaling and Neocortical Neuronal Migration

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