Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration-Reference-Cited by-同舟云学术

Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration

Published:2015-11-30 Issue:23 Volume:58 Page:9273-9286
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Meredith Erik L.¹,Mainolfi Nello¹,Poor Stephen²,Qiu Yubin²,Miranda Karl¹,Powers James¹,Liu Donglei¹,Ma Fupeng¹,Solovay Catherine¹,Rao Chang¹,Johnson Leland¹,Ji Nan¹,Artman Gerald¹,Hardegger Leo¹,Hanks Shawn²,Shen Siyuan²,Woolfenden Amber²,Fassbender Elizabeth²,Sivak Jeremy M.²,Zhang Yiqin²,Long Debby²,Cepeda Rosemarie²,Liu Fang²,Hosagrahara Vinayak P.³,Lee Wendy³,Tarsa Peter⁴,Anderson Karen²,Elliott Jason¹,Jaffee Bruce²

Affiliation:

1. Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, Massachusetts 02139, United States

2. Ophthalmology, Novartis Institutes for BioMedical Research, 500 Technology Square, Cambridge, Massachusetts 02139, United States

3. Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge Massachusetts 02139, United States

4. Chemical and Pharmaceutical Profiling, Novartis Institutes for BioMedical Research, 500 Technology Square, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01227

Reference30 articles.

1. Ranibizumab and Bevacizumab for Neovascular Age-Related Macular Degeneration

2. Ranibizumab versus Verteporfin for Neovascular Age-Related Macular Degeneration

3. The Biology of Vascular Endothelial Growth Factor

4. Experimentally induced changes in the endocytic traffic of P-glycoprotein alter drug resistance of cancer cells

5. Intravitreal triamcinolone does not alter basal vascular endothelial growth factor mRNA expression in rat retina

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