Challenges and opportunities of developing small-molecule therapies for age-related macular degeneration

Author:

Fei Xiang,Jung Sooyun,Kwon Sangil,Kim Jiweon,Corson Timothy W.,Seo Seung-YongORCID

Funder

National Research Foundation of Korea

Retina Research Foundation

Publisher

Springer Science and Business Media LLC

Reference102 articles.

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2. Adamis AP, Shima DT (2005) The role of vascular endothelial growth factor in ocular health and disease. Retina 25(2):111–118. https://doi.org/10.1097/00006982-200502000-00001

3. Adams CM, Anderson K, Artman G 3rd, Bizec JC, Cepeda R, Elliott J, Fassbender E, Ghosh M, Hanks S, Hardegger LA, Hosagrahara VP, Jaffee B, Jendza K, Ji N, Johnson L, Lee W, Liu D, Liu F, Long D, Ma F, Mainolfi N, Meredith EL, Miranda K, Peng Y, Poor S, Powers J, Qiu Y, Rao C, Shen S, Sivak JM, Solovay C, Tarsa P, Woolfenden A, Zhang C, Zhang Y (2018) The discovery of N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (acrizanib), a VEGFR-2 inhibitor specifically designed for topical ocular delivery, as a therapy for neovascular age-related macular degeneration. J Med Chem 61(4):1622–1635. https://doi.org/10.1021/acs.jmedchem.7b01731

4. Askew BC, Furuya T, Edwards DS (2018) Ocular distribution and pharmacodynamics of SF0166, a topically administered αvβ3 integrin antagonist, for the treatment of retinal diseases. J Pharmacol Exp Ther 366(2):244–250. https://doi.org/10.1124/jpet.118.248427

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