Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)

Author:

Yang Shyh-Ming1,Yasgar Adam1,Miller Bettina2,Lal-Nag Madhu1,Brimacombe Kyle1,Hu Xin1,Sun Hongmao1,Wang Amy1,Xu Xin1,Nguyen Kimloan1,Oppermann Udo34,Ferrer Marc1,Vasiliou Vasilis25,Simeonov Anton1,Jadhav Ajit1,Maloney David J.1

Affiliation:

1. National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States

2. Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States

3. Botnar Research Center, NIHR Oxford Biomedical Research Unit, Oxford OX3 7LD, U.K.

4. Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, U.K.

5. Department of Environmental Health Sciences, Yale School of Public Health, 60 College Street, New Haven, Connecticut 06510, United States

Funder

National Institute on Alcohol Abuse and Alcoholism

National Institute of Mental Health

National Center for Advancing Translational Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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