Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

Author:

Terzić Natasa1,Konstantinović Jelena2,Tot Mikloš2,Burojević Jovana2,Djurković-Djaković Olgica3,Srbljanović Jelena3,Štajner Tijana3,Verbić Tatjana2,Zlatović Mario2,Machado Marta4,Albuquerque Inês S.4,Prudêncio Miguel4,Sciotti Richard J.5,Pecic Stevan6,D’Alessandro Sarah7,Taramelli Donatella7,Šolaja Bogdan A.2

Affiliation:

1. Institute of Chemistry, Technology, and Metallurgy, 11000 Belgrade, Serbia

2. Faculty of Chemistry, University of Belgrade, Studentski trg 16, P.O. Box 51, 11158, Belgrade, Serbia

3. Institute for Medical Research, University of Belgrade, Dr. Subotića 4, 11129 Belgrade, Serbia

4. Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal

5. Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, United States

6. Division of Experimental Therapeutics, Department of Medicine, Columbia University, New York, New York 10032, United States

7. Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milan, Italy

Funder

Bill and Melinda Gates Foundation

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja

Fundação para a Ciência e a Tecnologia

Srpska Akademija Nauka i Umetnosti

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference85 articles.

1. Malaria,Fact Sheet no. 94;World Health Organization:Geneva,October, 2015; http://www.who.int/mediacentre/factsheets/fs094/en/. (accessed 16 October 2014).

2. aWHO, Facts on ACTS (Artemisinin-Based Combination Therapies);World Health Organization:Geneva,January 2006; http://www.malaria.org/ABOUT%20MALARIA/Facts%20on%20ACTs%20WHO.pdf(accessed 24 September 2014) .

3. bNoedl, H.Combination Therapy in Light of Emerging Artemisinin Resistance. In Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use;Staines, H. M., Krishna, S., Eds.Springer:Basel, Switzerland, 2012; pp213–225.

4. Malaria medicines: a glass half full?

5. Evidence of Artemisinin-Resistant Malaria in Western Cambodia

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