Affiliation:
1. Department of Chemistry, College of Sciences Shanghai University 99 Shangda Road 200444 Shanghai P. R. China
Abstract
Abstract3‐Fluorinated quinolines and pyridines are prevalent pharmacophores, yet their synthesis is often challenging. Herein, we demonstrate that dibromofluoromethane as bromofluorocarbene source enables the one‐carbon ring expansion of readily available indoles and pyrroles to structurally diverse 3‐fluorinated quinolines and pyridines. This straightforward protocol requires only a short reaction time of ten minutes and can be performed under air atmosphere. Preliminary investigations reveal that this strategy can also be applied to the synthesis of other valuable azines by using different 1,1‐dibromoalkanes as bromocarbene sources.
Funder
National Natural Science Foundation of China
Shanghai University
Subject
General Chemistry,Catalysis