Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway-Reference-Cited by-同舟云学术

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Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway

Published:2015-08-05 Issue:22 Volume:58 Page:8762-8782
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dounay Amy B.¹,Tuttle Jamison B.²,Verhoest Patrick R.²

Affiliation:

1. Department of Chemistry and Biochemistry, Colorado College, 14 E. Cache La Poudre Street, Colorado Springs, Colorado 80903, United States

2. Worldwide Medicinal Chemistry, Pfizer Worldwide Research & Development, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00461

Reference149 articles.

1. Kynurenines in the CNS: recent advances and new questions

2. Studien über den intermediären Stoffwechsel des Tryptophans XVIII—XXIV.

3. Tryptophan Pyrrolase of Rabbit Intestine

4. Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice

5. Novel Tryptophan Catabolic Enzyme IDO2 Is the Preferred Biochemical Target of the Antitumor Indoleamine 2,3-Dioxygenase Inhibitory Compound d-1-Methyl-Tryptophan

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1. A novel causative role of imbalanced kynurenine pathway in ulcerative colitis: Upregulation of KMO and KYNU promotes intestinal inflammation;Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease;2024-02

2. Selective inhibition of indoleamine and tryptophan 2,3-dioxygenases: Comparative study on kynurenine pathway in cell lines via LC-MS/MS-based targeted metabolomics;Journal of Pharmaceutical and Biomedical Analysis;2024-01

3. Potential molecular pathways of angiotensin receptor blockers in the brain toward cognitive improvement in dementia;Drug Discovery Today;2024-01

4. The Effect of Body Mass Index on the KYN/TRP Pathway in the Pathogenesis of Periodontitis;European Annals of Dental Sciences;2023-12-31

5. Tryptophan metabolism as a ‘reflex’ feature of neuroimmune communication: Sensor and effector functions for the indoleamine‐2, 3‐dioxygenase kynurenine pathway;Journal of Neurochemistry;2023-12-16

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