Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys-Reference-Cited by-同舟云学术

Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys

Published:2015-10-02 Issue:20 Volume:58 Page:8054-8065
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Martin Rainer E.¹,Aebi Johannes D.¹,Hornsperger Benoit¹,Krebs Hans-Jakob¹,Kuhn Bernd¹,Kuglstatter Andreas¹,Alker André M.¹,Märki Hans Peter¹,Müller Stephan²,Burger Dominique²,Ottaviani Giorgio³,Riboulet William⁴,Verry Philippe⁵,Tan Xuefei⁶,Amrein Kurt⁷,Mayweg Alexander V.¹

Affiliation:

1. Medicinal Chemistry, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, CH-4070 Basel, Switzerland

2. Discovery Technologies, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, CH-4070 Basel, Switzerland

3. Pharmaceutical Sciences, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Shanghai, F. Hoffmann-La Roche Ltd., 720 Cai Lun Road, Building 5, Pudong, Shanghai 201203, China

4. Neuroscience, Ophthalmology and Rare Diseases, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, CH-4070 Basel, Switzerland

5. Discovery Cardiovascular and Metabolic Disease, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, CH-4070 Basel, Switzerland

6. Medicinal Chemistry, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Shanghai, F. Hoffmann-La Roche Ltd., 720 Cai Lun Road, Building 5, Pudong, Shanghai 201203, China

7. Discovery Infectious Disease, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, CH-4070 Basel, Switzerland

Funder

F. Hoffman-La Roche

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00851

Reference25 articles.

1. Renin–Angiotensin System Blockade and Cardiovascular and Renal Protection

2. Association of the Renin-Sodium Profile with the Risk of Myocardial Infarction in Patients with Hypertension

3. RAAS Inhibition and Renal Protection