Design, Synthesis, and Biological Evaluations of Pyridyl 4,5,6,7-Tetrahydro-4,7-Methanobenzo[<i>d</i>]isoxazoles as Potent and Selective Inhibitors of 11β-Hydroxylase-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluations of Pyridyl 4,5,6,7-Tetrahydro-4,7-Methanobenzo[d]isoxazoles as Potent and Selective Inhibitors of 11β-Hydroxylase

Published:2022-08-17 Issue:17 Volume:65 Page:11876-11888
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yin Lina¹,Pan Youtian¹,Xue Yuanyuan¹,Chen Xiaoli¹,You Taiyun¹,Huang Jiahui¹,Xu Qihao¹,Hu Qingzhong¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, 232 East Waihuan Road, 510006 Panyu, Guangzhou, P. R. China

Funder

Guangdong Science and Technology Department

Government of Guangdong Province

Department of Education of Guangdong Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01037

Reference23 articles.

1. The CYP11B subfamily

2. Therapeutic compounds for Cushing’s syndrome: a patent review (2012-2016)

3. Cortisol Synthesis in Epidermis Is Induced by IL-1 and Tissue Injury

4. Potent 11β-Hydroxylase Inhibitors with Inverse Metabolic Stability in Human Plasma and Hepatic S9 Fractions To Promote Wound Healing

5. Osilodrostat: A Novel Steroidogenesis Inhibitor to Treat Cushing’s Disease

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