Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand

Author:

Mistry Shailesh N.1,Shonberg Jeremy1,Draper-Joyce Christopher J.2,Klein Herenbrink Carmen2,Michino Mayako3,Shi Lei345,Christopoulos Arthur2,Capuano Ben1,Scammells Peter J.1,Lane J. Robert2

Affiliation:

1. Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria Australia

2. Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria Australia

3. Computational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse—Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, United States

4. Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York 10065, United States

5. Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York 10021, United States

Funder

Department of Health, Australian Government

Monash University

National Natural Science Foundation of China

Program for New Century Excellent Talents in University

Northwestern Polytechnical University

Department of Industry, Innovation, Science, Research and Tertiary Education, Australian Government

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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