Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia
Author:
Affiliation:
1. Chorus, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States
Funder
Eli Lilly and Company
Clearinghouse for the Open Research of the United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01161
Reference8 articles.
1. Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR
2. Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
3. Identification of a Nuclear Receptor for Bile Acids
4. The Farnesoid X-receptor Is an Essential Regulator of Cholesterol Homeostasis
5. A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
Cited by 49 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets;Signal Transduction and Targeted Therapy;2024-04-26
2. 3D-QSAR and Molecular Dynamics Study of Isoxazole Derivatives to Identify the Structural Requirements for Farnesoid X Receptor (FXR) Agonists;Molecules;2024-03-08
3. Patented Farnesoid X receptor modulators: a review (2019 – present);Expert Opinion on Therapeutic Patents;2024-02-26
4. Leveraging flow chemistry for the synthesis of trisubstituted isoxazoles;Journal of Flow Chemistry;2023-11-08
5. FXR agonists in NASH treatment;Journal of Hepatology;2023-11
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3