Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure–Activity Relationship Study-Reference-Cited by-同舟云学术

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure–Activity Relationship Study

Published:2015-07-07 Issue:14 Volume:58 Page:5419-5436
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Xu Li-Li¹²,Zhu Jun-Feng¹²,Xu Xiao-Li¹²,Zhu Jie¹²,Li Li¹²,Xi Mei-Yang¹²,Jiang Zheng-Yu¹²,Zhang Ming-Ye¹²,Liu Fang¹²,Lu Meng-chen¹²,Bao Qi-Chao¹²,Li Qi³,Zhang Chao¹²,Wei Jin-Lian¹²,Zhang Xiao-Jin¹²⁴,Zhang Lian-Shan⁵,You Qi-Dong¹²⁵,Sun Hao-Peng¹²³

Affiliation:

1. Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China

2. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China

3. Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China

4. Department of Organic Chemistry, School of Science, China Pharmaceutical University, Nanjing 210009, China

5. National Engineering and Research Center for Target Drugs, Jiangsu Hengrui Medicine Co. Ltd., Lianyungang 222000, China

Funder

National Natural Science Foundation of China

Ministry of Education of the People's Republic of China

Ministry of Science and Technology of the People's Republic of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00170

Reference26 articles.

1. The emerging role of the Nrf2–Keap1 signaling pathway in cancer

2. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

3. A Review of the Evidence that Ochratoxin A Is an Nrf2 Inhibitor: Implications for Nephrotoxicity and Renal Carcinogenicity

4. The Predicted Molecular Weight of Nrf2: It Is What It Is Not

5. Keap Calm, and Carry on Covalently

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