Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38α MAP Kinase Inhibitor-Reference-Cited by-同舟云学术

Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38α MAP Kinase Inhibitor

Published:2015-09-22 Issue:19 Volume:58 Page:7775-7784
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Chunjian¹,Lin James¹,Hynes John¹,Wu Hong¹,Wrobleski Stephen T.¹,Lin Shuqun¹,Dhar T. G. Murali¹,Vrudhula Vivekananda M.¹,Sun Jung-Hui¹,Chao Sam¹,Zhao Rulin¹,Wang Bei¹,Chen Bang-Chi¹,Everlof Gerry¹,Gesenberg Christoph¹,Zhang Hongjian¹,Marathe Punit H.¹,McIntyre Kim W.¹,Taylor Tracy L.¹,Gillooly Kathleen¹,Shuster David J.¹,McKinnon Murray¹,Dodd John H.¹,Barrish Joel C.¹,Schieven Gary L.¹,Leftheris Katerina¹

Affiliation:

1. Research and Development, Bristol-Myers Squibb, Princeton, New Jersey 08543, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00839

Reference28 articles.

1. Mechanisms and functions of p38 MAPK signalling

2. The Biology of p38 Kinase: A Central Role in Inflammation

3. The p38 MAP kinase pathway as a therapeutic target in inflammatory disease