p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases-Reference-Cited by-同舟云学术

p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

Published:2003-09 Issue:9 Volume:2 Page:717-726
ISSN:1474-1776
Container-title:Nature Reviews Drug Discovery
language:en
Short-container-title:Nat Rev Drug Discov

Author:

Kumar Sanjay,Boehm Jeffrey,Lee John C.

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology,General Medicine

Link

http://www.nature.com/articles/nrd1177.pdf

Reference75 articles.

1. Pearson, G. et al. Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions. Endocr. Rev. 22, 153–183 (2001). A comprehensive review of all three MAPK pathways.

2. Lee, J. C. et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372, 739–746 (1994). Describes in detail the identification of the molecular target of a class of pyridinyl imidazole compounds known to inhibit cytokine production as p38 MAPK.

3. Han, J., Lee, J. D., Bibbs, L. & Ulevitch, R. J. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265, 808–811 (1994). This paper identifies a prominent phosphoprotein extracted from LPS-stimulated mouse macrophage cell line as murine p38 MAPK.

4. Jiang, Y. et al. Characterization of the structure and function of a new mitogen-activated protein kinase (p38β). J. Biol. Chem. 271, 17920–17926 (1996).

5. Kumar, S. et al. Novel homologues of CSBP/p38 MAP kinase-activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem. Biophys. Res. Commun. 235, 533–538 (1997).

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