Role of Lipoylation of the Immunodominant Epitope of Pyruvate Dehydrogenase Complex: Toward a Peptide-Based Diagnostic Assay for Primary Biliary Cirrhosis

Author:

Pacini Giulia,Carotenuto Alfonso1,Rentier Cedric23,Nuti Francesca2,Real-Fernandez Feliciana,Brancaccio Diego1,Sabatino Giuseppina2,Larregola Maud3,Peroni Elisa3,Migliorini Paola4,Novellino Ettore1,Battezzati Pier Maria5,Selmi Carlo67,Papini Anna Maria23,Rovero Paolo

Affiliation:

1. Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, 80131 Napoli, Italy

2. Department of Chemistry “Ugo Schiff”, University of Florence, Via della Lastruccia 13, 50019 Sesto Fiorentino, Italy

3. PeptLab@UCP Platform and Laboratory of Chemical Biology EA4505, University of Cergy-Pontoise, 5 Mail Gay-Lussac, 95031 Cergy-Pontoise Cedex, France

4. Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy

5. Department of Health Sciences, Division of Medicine and Gastroenterology and Liver Unit, University of Milan, Ospedale San Paolo, Via Antonio Di Rudinì 8, 20142 Milano, Italy

6. Division of Rheumatology and Clinical Immunology, IRCCS Istituto Clinico Humanitas, Via Alessandro Manzoni 56, 20089 Rozzano, Milano, Italy

7. BIOMETRA Department, University of Milan, Via Festa del Perdono 7, 20122 Milano, Italy

Funder

Agence Nationale de la Recherche

Ente Cassa di Risparmio di Firenze

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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