N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase-Reference-Cited by-同舟云学术

N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase

Published:2015-05-26 Issue:11 Volume:58 Page:4610-4623
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pescatori Luca¹,Métifiot Mathieu²,Chung Suhman³,Masoaka Takashi³,Cuzzucoli Crucitti Giuliana¹,Messore Antonella¹,Pupo Giovanni¹,Madia Valentina Noemi¹,Saccoliti Francesco¹,Scipione Luigi¹,Tortorella Silvano¹,Di Leva Francesco Saverio⁴,Cosconati Sandro⁵,Marinelli Luciana⁴,Novellino Ettore⁴,Le Grice Stuart F. J.³,Pommier Yves²,Marchand Christophe²,Costi Roberta¹,Di Santo Roberto¹

Affiliation:

1. Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti, “Sapienza” Università di Roma, P-le Aldo Moro 5, I-00185, Roma, Italy

2. Laboratory of Molecular Pharmacology and Developmental Therapeutic Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 5068, Bethesda, Maryland 20892-4255, United States

3. Resistance Mechanisms Laboratory, HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States

4. Dipartimento di Farmacia, Università di Napoli “Federico II”, Via D. Montesano 49, 80131 Napoli, Italy

5. DiSTABiF, Seconda Università di Napoli, Via Vivaldi 43, 81100 Caserta, Italy

Funder

National Cancer Institute

Seventh Framework Programme

Ministero dell'Istruzione, dell'Università e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00159