Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ-Opioid Receptor-Reference-Cited by-同舟云学术

Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ-Opioid Receptor

Published:2015-05-07 Issue:10 Volume:58 Page:4220-4229
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Burford Neil T.¹,Livingston Kathryn E.²,Canals Meritxell³,Ryan Molly R.⁴,Budenholzer Lauren M. L.⁴,Han Ying¹,Shang Yi⁵,Herbst John J.¹,O’Connell Jonathan⁶,Banks Martyn¹,Zhang Litao¹,Filizola Marta⁵,Bassoni Daniel L.⁷,Wehrman Tom S.⁸,Christopoulos Arthur³,Traynor John R.²,Gerritz Samuel W.¹,Alt Andrew¹

Affiliation:

1. Research and Development/Discovery, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492, United States

2. Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109, United States

3. Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences & Department of Pharmacology, Monash University, 399 Royal Parade, Parkville, Victoria 3052, Australia

4. Departments of Molecular Biophysics and Biochemistry & Pharmacology, Yale University, New Haven, Connecticut 06520, United States

5. Department of Structural and Chemical Biology Icahn School of Medicine at Mount Sinai (ISMMS), New York, New York 10029-6574, United States

6. FORMA Therapeutics, Arsenal Street, Suite 100, Watertown, Massachusetts 02472, United States

7. DiscoveRx Corporation, 42501 Albrae Street, Suite 100, Fremont, California 94538, United States

8. Primity Bio, 3350 Scott Boulevard, Ste 6101, Santa Clara, California 95054, United States

Funder

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b00007

Reference33 articles.

1. Delta opioid receptor analgesia

2. Opioid receptors: distinct roles in mood disorders

3. Comparison of Receptor Mechanisms and Efficacy Requirements for δ-Agonist-Induced Convulsive Activity and Antinociception in Mice

4. Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats

5. Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)

Cited by 56 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Immobilized proline-based electro-organocatalyst for the synthesis of bis-β-diketone via Knoevenagel condensation reaction;Electrochimica Acta;2024-11

2. Identification of c[D-Trp-Phe-β-Ala-β-Ala], the First κ-Opioid Receptor-Specific Negative Allosteric Modulator;ACS Pharmacology & Translational Science;2024-09-11

3. -Proline catalyzed synthesis of biologically promising heterocycles under sustainable conditions;Tetrahedron Chem;2024-08

4. Bivalent and bitopic ligands of the opioid receptors: The prospects of a dual approach;Medicinal Research Reviews;2024-05-15

5. Trifluoroacetic acid-mediated synthesis of xanthene constructs and their extensive anti-tuberculosis evaluation;RSC Medicinal Chemistry;2024