Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)-Reference-Cited by-同舟云学术

Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)

Published:2008-09-13 Issue:19 Volume:51 Page:5893-5896
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bourdonnec Bertrand Le¹,Windh Rolf T.¹,Ajello Christopher W.¹,Leister Lara K.¹,Gu Minghua¹,Chu Guo-Hua¹,Tuthill Paul A.¹,Barker William M.¹,Koblish Michael¹,Wiant Daniel D.¹,Graczyk Thomas M.¹,Belanger Serge¹,Cassel Joel A.¹,Feschenko Marina S.¹,Brogdon Bernice L.¹,Smith Steven A.¹,Christ David D.¹,Derelanko Michael J.¹,Kutz Steve¹,Little Patrick J.¹,DeHaven Robert N.¹,DeHaven-Hudkins Diane L.¹,Dolle Roland E.¹

Affiliation:

1. Departments of Chemistry, Pharmacology, DMPK, and Preclinical Safety Assessment, Adolor Corporation, 700 Pennsylvania Drive, Exton, Pennsylvania 19341

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8008986

Reference26 articles.

1. Antihyperalgesic effects of δ opioid agonists in a rat model of chronic inflammation

2. Evidence for a Selective Role of the δ-Opioid Agonist [8R-(4bS*,8aα,8aβ,12bβ)]7,10-Dimethyl-1-methoxy-11-(2-methylpropyl)oxycarbonyl 5,6,7,8,12,12b-hexahydro-(9H)-4,8-methanobenzofuro[3,2-e]pyrrolo[2,3-g]isoquinoline Hydrochloride (SB-235863) in Blocking Hyperalgesia Associated with Inflammatory and Neuropathic Pain Responses

3. Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain

4. The role of δ-opioid receptor subtypes in neuropathic pain

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