Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design-Reference-Cited by-同舟云学术

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

Published:2016-03-08 Issue:6 Volume:59 Page:2760-2779
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Volgraf Matthew,Sellers Benjamin D.,Jiang Yu¹,Wu Guosheng¹,Ly Cuong Q.,Villemure Elisia,Pastor Richard M.,Yuen Po-wai¹,Lu Aijun¹,Luo Xifeng¹,Liu Mingcui¹,Zhang Shun¹,Sun Liang¹,Fu Yuhong¹,Lupardus Patrick J.,Wallweber Heidi J.A.,Liederer Bianca M.,Deshmukh Gauri,Plise Emile,Tay Suzanne,Reynen Paul,Herrington James,Gustafson Amy,Liu Yichin,Dirksen Akim²,Dietz Matthias G. A.²,Liu Yanzhou,Wang Tzu-Ming,Hanson Jesse E.,Hackos David,Scearce-Levie Kimberly,Schwarz Jacob B.

Affiliation:

1. Pharmaron-Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, PR China

2. Ion Channels Group, Evotec AG; Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b02010

Reference28 articles.

1. Glutamate Receptor Ion Channels: Structure, Regulation, and Function

2. NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease