Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity-Reference-Cited by-同舟云学术

Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity

Published:2022-08-08 Issue:16 Volume:65 Page:11214-11228
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Yu¹,Li Yingchun²,Chen Xiang²,Chen Xuan²,Chen Chao³,Wang Li³,Dong Xu²,Wang Guoli²,Gu Ruxin⁴,Li Fei²,Han Feng¹⁴⁵^ORCID,Chen Dongyin¹²^ORCID

Affiliation:

1. Key Laboratory of Cardiovascular & Cerebrovascular Medicine, Drug Target and Drug Discovery Center, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China

2. Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China

3. Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China

4. Institute of Brain Science, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 211166, China

5. Gusu School, Nanjing Medical University, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China

Funder

Ministry of Science and Technology of the People's Republic of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00677

Reference37 articles.

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2. The Bidirectional Relationship of Depression and Inflammation: Double Trouble

3. Remission Rates Following Antidepressant Therapy With Bupropion or Selective Serotonin Reuptake Inhibitors

4. Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

5. Homeostasis Imbalance of Microglia and Astrocytes Leads to Alteration in the Metabolites of the Kynurenine Pathway in LPS-Induced Depressive-Like Mice

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