Structure-Based Discovery of Inhibitors of the SARS-CoV-2 Nsp14 N7-Methyltransferase

Author:

Singh Isha1,Li Fengling2,Fink Elissa A.13ORCID,Chau Irene2,Li Alice45ORCID,Rodriguez-Hernández Annía6,Glenn Isabella1,Zapatero-Belinchón Francisco J.7ORCID,Rodriguez M. Luis89,Devkota Kanchan2,Deng Zhijie10,White Kris89,Wan Xiaobo1ORCID,Tolmachova Nataliya A.1112,Moroz Yurii S.1314ORCID,Kaniskan H. Ümit10ORCID,Ott Melanie7151617,García-Sastre Adolfo89151819,Jin Jian1015ORCID,Fujimori Danica Galonić1615ORCID,Irwin John J.115,Vedadi Masoud24155ORCID,Shoichet Brian K.115ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94143, United States

2. Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada

3. Graduate Program in Biophysics, University of California San Francisco, San Francisco, California 94143, United States

4. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

5. Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada

6. Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94158, United States

7. Gladstone Institutes, San Francisco, California 94158, United States

8. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

9. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

10. Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

11. Enamine Ltd, Kyïv 02094, Ukraine

12. Institute of Bioorganic Chemistry and Petrochemistry, National Ukrainian Academy of Science, Kyïv 02660, Ukraine

13. National Taras Shevchenko University of Kyïv, Kyïv 01601, Ukraine

14. Chemspace, Riga LV-1082, Latvia

15. QBI COVID-19 Research Group (QCRG), San Francisco, California 94158, United States

16. Department of Medicine, University of California, San Francisco, San Francisco, California 94158, United States

17. Chan Zuckerberg Biohub, San Francisco, California 94158, United States

18. Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

19. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

Funder

Defense Advanced Research Projects Agency

National Institute of Allergy and Infectious Diseases

National Institute of General Medical Sciences

Structural Genomics Consortium

James B. Pendleton Charitable Trust

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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