Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands

Published:2022-07-18 Issue:14 Volume:65 Page:9918-9938
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gado Francesca¹,Ferrisi Rebecca¹,Polini Beatrice¹²,Mohamed Kawthar A.³,Ricardi Caterina²,Lucarini Elena⁴,Carpi Sara¹⁵,Domenichini Federica¹,Stevenson Lesley A.⁶,Rapposelli Simona¹⁷^ORCID,Saccomanni Giuseppe¹,Nieri Paola¹,Ortore Gabriella¹,Pertwee Roger G.⁶,Ghelardini Carla⁴,Di Cesare Mannelli Lorenzo⁴,Chiellini Grazia²⁷,Laprairie Robert B.³⁸,Manera Clementina¹⁷^ORCID

Affiliation:

1. Department of Pharmacy, University of Pisa, Pisa 56126, Italy

2. Department of Pathology, University of Pisa, Pisa 56126, Italy

3. College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon SK S7N 5E5, Canada

4. Department of Neuroscience, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, Florence 50139, Italy

5. NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore, Piazza San Silvestro, Pisa 56126, Italy

6. Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, U.K.

7. CISUP, Centre for Instrumentation Sharing Pisa University, Lungarno Pacinotti 43, Pisa 56126, Italy

8. Department of Pharmacology, College of Medicine, Dalhousie University, Halifax B3H 4R2, Nova Scotia, Canada

Funder

Canadian Institutes of Health Research

Ministero della Salute

GlaxoSmithKline

Natural Sciences and Engineering Research Council of Canada

Universit? di Pisa

Ministero dell'Istruzione, dell'Universit? e della Ricerca

Publisher