Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions-Reference-Cited by-同舟云学术

Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions

Published:2022-11-11 Issue:22 Volume:65 Page:15416-15432
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Davison Gemma¹^ORCID,Martin Mathew P.²,Turberville Shannon²,Dormen Selma¹,Heath Richard²,Heptinstall Amy B.¹,Lawson Marie¹,Miller Duncan C.¹^ORCID,Ng Yi Min²,Sanderson James N.¹^ORCID,Hope Ian²^ORCID,Wood Daniel J.²,Cano Céline¹^ORCID,Endicott Jane A.²,Hardcastle Ian R.¹^ORCID,Noble Martin E. M.²,Waring Michael J.¹^ORCID

Affiliation:

1. Cancer Research Horizons Therapeutic Innovation, Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K.

2. Cancer Research Horizons Therapeutic Innovation, Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Newcastle University, Paul O’Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4AD, U.K.

Funder

Medical Research Council

Newcastle University

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01357

Reference23 articles.

1. Bromodomains: a new target class for drug development