FragLites—Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation-Reference-Cited by-同舟云学术

FragLites—Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation

Published:2019-03-12 Issue:7 Volume:62 Page:3741-3752
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wood Daniel J.¹,Lopez-Fernandez J. Daniel²,Knight Leanne E.²,Al-Khawaldeh Islam²,Gai Conghao²,Lin Shengying²,Martin Mathew P.¹,Miller Duncan C.²,Cano Céline²^ORCID,Endicott Jane A.¹,Hardcastle Ian R.²,Noble Martin E. M.¹,Waring Michael J.²^ORCID

Affiliation:

1. Northern Institute for Cancer Research, Medical School, Newcastle University, Paul O’Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.

2. Northern Institute for Cancer Research, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K.

Funder

Medical Research Council

Newcastle University

Jordan University of Science and Technology

Cancer Research UK

JGW Patterson Foundation

Astex Pharmaceuticals

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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