Highly Selective SERCA2a Activators: Preclinical Development of a Congeneric Group of First-in-Class Drug Leads against Heart Failure-Reference-Cited by-同舟云学术

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Highly Selective SERCA2a Activators: Preclinical Development of a Congeneric Group of First-in-Class Drug Leads against Heart Failure

Published:2022-05-17 Issue:10 Volume:65 Page:7324-7333
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Luraghi Andrea¹,Ferrandi Mara²,Barassi Paolo²,Arici Martina¹,Hsu Shih-Che³,Torre Eleonora¹,Ronchi Carlotta¹,Romerio Alessio¹,Chang Gwo-Jyh⁴^ORCID,Ferrari Patrizia²,Bianchi Giuseppe²⁵,Zaza Antonio¹,Rocchetti Marcella¹,Peri Francesco¹^ORCID

Affiliation:

1. Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano 20126, Italy

2. Windtree Therapeutics Inc., Warrington, Pennsylvania 18976, United States

3. CVie Therapeutics Limited, Taipei 11047 Taiwan

4. Cardiovascular Medicine, Chang Gung University, Tao-Yuan 333323 Taiwan

5. Università Vita-Salute San Raffaele, Milano 20132, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00347

Reference27 articles.

1. Heart failure

2. Lifetime Risk for Developing Congestive Heart Failure

3. Regulation of Ca2+ and Na+ in Normal and Failing Cardiac Myocytes

4. Structures of the heart specific SERCA 2a Ca 2+ ‐ ATP ase

5. Calcium Cycling and Signaling in Cardiac Myocytes

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1. Selective SERCA2a activator as a candidate for chronic heart failure therapy;Journal of Translational Medicine;2024-01-19

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3. 1,4-Benzothiazepines with Cyclopropanol Groups and Their Structural Analogues Exhibit Both RyR2-Stabilizing and SERCA2a-Stimulating Activities;Journal of Medicinal Chemistry;2023-11-22

4. The role of mitochondria in myocardial damage caused by energy metabolism disorders: From mechanisms to therapeutics;Free Radical Biology and Medicine;2023-11

5. Current Targets and Future Directions of Positive Inotropes for Heart Failure;Current Medicinal Chemistry;2023-10-31

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