1,4-Benzothiazepines with Cyclopropanol Groups and Their Structural Analogues Exhibit Both RyR2-Stabilizing and SERCA2a-Stimulating Activities-Reference-Cited by-同舟云学术

1,4-Benzothiazepines with Cyclopropanol Groups and Their Structural Analogues Exhibit Both RyR2-Stabilizing and SERCA2a-Stimulating Activities

Published:2023-11-22 Issue:23 Volume:66 Page:15761-15775
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mitronova Gyuzel Y.¹²^ORCID,Quentin Christine¹^ORCID,Belov Vladimir N.¹^ORCID,Wegener Jörg W.³²^ORCID,Kiszka Kamila A.¹,Lehnart Stephan E.³²

Affiliation:

1. Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, Göttingen 37077, Germany

2. German Centre for Cardiovascular Research (DZHK), Partner Site Göttingen, Göttingen 37075, Germany

3. Department of Cardiology & Pulmonology, Heart Research Center Göttingen, University Medical Center Göttingen, Robert-Koch-Strasse 42a, Göttingen 37075, Germany

Funder

Deutsches Zentrum f?r Herz-Kreislaufforschung

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01235

Reference61 articles.

1. Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

2. Targeting ryanodine receptors to treat human diseases

3. Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice

4. Cardiac excitation–contraction coupling

5. Dysfunctional ryanodine receptors in the heart: New insights into complex cardiovascular diseases

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