Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition-Reference-Cited by-同舟云学术

Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition

Published:2022-11-01 Issue:21 Volume:65 Page:14599-14613
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kawamura Madoka¹^ORCID,Kobashi Yohei¹,Tanaka Hiroaki¹,Bohno-Mikami Ayako¹,Hamada Makoto¹,Ito Yuji¹,Hirata Takashi¹,Ohara Hiroki¹,Kojima Naoki¹,Koretsune Hiroko¹,Gunji Emi¹,Fukunaga Takuya¹,Inatani Shoko²^ORCID,Hasegawa Yoshitaka²,Suzuki Akinori³,Takahashi Teisuke¹,Kakinuma Hiroyuki¹

Affiliation:

1. Discovery Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403, Yoshino-Cho, Kita-Ku, Saitama, Saitama331-9530, Japan

2. Drug Safety and Pharmacokinetics Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403, Yoshino-Cho, Kita-Ku, Saitama, Saitama331-9530, Japan

3. Pharmaceutical Sciences Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403, Yoshino-Cho, Kita-Ku, Saitama, Saitama331-9530, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01089

Reference29 articles.

1. Localization of cytochrome P-450 4A isoforms along the rat nephron

2. 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries.

3. Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase

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