Introduction of a carboxylic acid group into pyrazolylpyridine derivatives increased selectivity for inhibition of the 20-HETE synthase CYP4A11/4F2

Author:

Kawamura Madoka,Kobashi Yohei,Tanaka Hiroaki,Bohno-Mikami Ayako,Hamada MakotoORCID,Ito YujiORCID,Suzuki Kazuaki,Funayama Kosuke,Hirata Takashi,Ohara Hiroki,Koretsune Hiroko,Kojima Naoki,Fukunaga Takuya,Hirate MakiORCID,Inatani ShokoORCID,Hasegawa Yoshitaka,Takahashi Teisuke,Kakinuma HiroyukiORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference52 articles.

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3. Metabolism of arachidonic acid to 20-hydroxy-5,8,11,14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11;Powell;J Pharmacol Exp Ther,1998

4. Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11;Lasker;J Biol Chem,2000

5. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension;Gainer;Circulation,2005

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