Small-Molecule Gankyrin Inhibition as a Therapeutic Strategy for Breast and Lung Cancer-Reference-Cited by-同舟云学术

Small-Molecule Gankyrin Inhibition as a Therapeutic Strategy for Breast and Lung Cancer

Published:2022-06-27 Issue:13 Volume:65 Page:8975-8997
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kanabar Dipti¹,Goyal Mimansa¹,Kane Emma I.²,Chavan Tejashri¹,Kabir Abbas¹,Wang Xuechun¹,Shukla Snehal¹,Almasri Joseph³,Goswami Sona¹,Osman Gizem⁴,Kokolis Marino¹,Spratt Donald E.²,Gupta Vivek¹^ORCID,Muth Aaron¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, New York 11439, United States

2. Gustaf H. Carlson School of Chemistry & Biochemistry, Clark University, Worcester Massachusetts 01610, United States

3. Department of Chemistry, College of Liberal Arts and Sciences, St. John’s University, Queens, New York 11439, United States

4. Department of Biological Sciences, College of Liberal Arts and Sciences, St. John’s University, Queens, New York 11439, United States

Funder

St. John's University

National Institute of General Medical Sciences

Department of Pharmaceutical Sciences, St. John’s University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00190

Reference60 articles.

1. Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas

2. Gankyrin Is an Ankyrin-repeat Oncoprotein That Interacts with CDK4 Kinase and the S6 ATPase of the 26 S Proteasome

3. Discovery of multiple interacting partners of gankyrin, a proteasomal chaperone and an oncoprotein-Evidence for a common hot spot site at the interface and its functional relevance

4. Gankyrin: a new oncoprotein and regulator of pRb and p53

5. Gankyrin drives malignant transformation of chronic liver damage-mediated fibrosis via the Rac1/JNK pathway

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