Synthesis and Evaluation of 2,5-Substituted Pyrimidines as Small-Molecule Gankyrin Binders
Author:
Affiliation:
1. Department of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, St. John’s University, Queens, NY 11439, USA
2. Gustaf H. Carlson School of Chemistry & Biochemistry, Clark University, Worcester, MA 01610, USA
Funder
National Institute of General Medical Sciences
Publisher
Informa UK Limited
Link
https://www.tandfonline.com/doi/pdf/10.4155/fmc-2023-0124
Reference41 articles.
1. Structure of the Oncoprotein Gankyrin in Complex with S6 ATPase of the 26S Proteasome
2. Gankyrin as a potential therapeutic target for cancer
3. Novel Insights into the INK4-CDK4/6-Rb Pathway: Counter Action of Gankyrin against INK4 Proteins Regulates the CDK4-Mediated Phosphorylation of Rb
4. Gankyrin regulates cell signaling network
5. The oncogene Gankyrin is expressed in testicular cancer and contributes to cisplatin sensitivity in embryonal carcinoma cells
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