Explaining Blood–Brain Barrier Permeability of Small Molecules by Integrated Analysis of Different Transport Mechanisms-Reference-Cited by-同舟云学术

Explaining Blood–Brain Barrier Permeability of Small Molecules by Integrated Analysis of Different Transport Mechanisms

Published:2023-05-22 Issue:11 Volume:66 Page:7253-7267
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cornelissen Fleur M.G.¹,Markert Greta²^ORCID,Deutsch Ghislaine¹²,Antonara Maria¹²,Faaij Noa¹,Bartelink Imke³,Noske David¹,Vandertop W. Peter¹,Bender Andreas²^ORCID,Westerman Bart A.¹⁴^ORCID

Affiliation:

1. Department of Neurosurgery, Amsterdam UMC, location VUMC, Cancer Center, Amsterdam 1105, AZ, the Netherlands

2. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Rd, Cambridge CB2 1EW, U.K.

3. Department of Pharmacy, Amsterdam UMC, location VUMC, Cancer Center, Amsterdam 1105, AZ, the Netherlands

4. Window Consortium ()

Funder

Brain Tumour Charity

Health~Holland

KWF Kankerbestrijding

Innovation Exchange Amsterdam

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01824

Reference88 articles.

1. A Method to Predict Blood-Brain Barrier Permeability of Drug-Like Compounds Using Molecular Dynamics Simulations

2. Demystifying Brain Penetration in Central Nervous System Drug Discovery

3. Strategies for Structural Modification of Small Molecules to Improve Blood–Brain Barrier Penetration: A Recent Perspective

4. Small Molecule Kinase Inhibitors for the Treatment of Brain Cancer

5. The blood-brain barrier: Bottleneck in brain drug development

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