Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton’s Tyrosine Kinase for the Treatment of Lymphoma

Author:

Zhang Jingyu1,Che Jinxin1,Luo Xiaomin23,Wu Mingfei1,Kan Weijuan3,Jin Yuheng1,Wang Hanlin34,Pang Ao1,Li Cong3,Huang Wenhai5,Zeng Shenxin5,Zhuang Weihao1,Wu Yizhe1,Xu Yongjin6,Zhou Yubo237,Li Jia237,Dong Xiaowu189ORCID

Affiliation:

1. Hangzhou Institute of Innovative Medicine, Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China

2. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China

3. National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China

4. School of Pharmacy, Fudan University, Shanghai 200032, China

5. Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou 310058, P. R. China

6. Department of Lymphoma, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer, Chinese Academy of Sciences, Hangzhou 310005, P. R. China

7. Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, Tsuihang New District, Guangdong 528400, P. R. China

8. Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou 310018, P. R. China

9. Cancer Center, Zhejiang University, Hangzhou 310058, P. R. China

Funder

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Zhejiang Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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