Design, Synthesis, and Biological Evaluation of Novel Evodiamine Derivatives as Potential Antihepatocellular Carcinoma Agents

Author:

Lei Fang1,Xiong Yongxia2,Wang Yuqing1,Zhang Honghua1,Liang Ziyi3,Li Junfang1,Feng Yiyue1,Hao Xiangyong4,Wang Zhen123ORCID

Affiliation:

1. School of Pharmacy, Lanzhou University, Lanzhou 730000, China

2. School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China

3. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China

4. Department of General Surgery, Gansu Provincial Hospital, Lanzhou 730000, China

Funder

Natural Science Foundation of Gansu Province

Thousand Young Talents Program of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference47 articles.

1. WHO. Global Health Estimates 2020: Death by Cause, Age, Sex, by Country and by Region, 2000-2019[Z/OL], 2021.

2. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

3. Treatment of intermediate-stage hepatocellular carcinoma

4. World Health Organizaion. Cancer today. Accessed. November 11, 2020. Available at: https://gco.iarc.fr/today/home.

5. Diagnosis and treatment of hepatocellular carcinoma: An update

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