Structure-Based Discovery of Selective Histone Deacetylase 8 Degraders with Potent Anticancer Activity-Reference-Cited by-同舟云学术

Structure-Based Discovery of Selective Histone Deacetylase 8 Degraders with Potent Anticancer Activity

Published:2022-12-14 Issue:2 Volume:66 Page:1186-1209
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Huang Jinbo¹²³^ORCID,Zhang Jun¹²³,Xu Wenchao⁴,Wu Qiong¹²³,Zeng Rongsheng⁴,Liu Zhichao¹²³,Tao Wenhui¹²³,Chen Qian¹²³,Wang Yongqing⁵,Zhu Wei-Guo¹²⁶⁴³^ORCID

Affiliation:

1. Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, and International Cancer Center, Shenzhen University School of Medicine, Shenzhen 518055, China

2. Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen 518055, China

3. Health Science Centre School of Basic Medical Sciences, Shenzhen University, Shenzhen 518055, China

4. Marshall Laboratory of Biomedical Engineering, Shenzhen University School of Medicine, Shenzhen 518055, China

5. Division of Rheumatology and Immunology, University of Toledo Medical Center, 3120 Glendale Avenue, Toledo 43614, Ohio, United States

6. Shenzhen Bay Laboratory, Shenzhen University School of Medicine, Shenzhen 518055, China

Funder

Ministry of Science and Technology of the People's Republic of China

Science, Technology and Innovation Commission of Shenzhen Municipality

National Natural Science Foundation of China

Shenzhen University

Ministry of Education Key Laboratory of Functional Molecular Solids, Anhui Normal University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00739

Reference58 articles.

1. Chemical phylogenetics of histone deacetylases

2. Translating the Histone Code

3. Histone deacetylation in epigenetics: An attractive target for anticancer therapy

4. Epigenetics—An Epicenter of Gene Regulation: Histones and Histone-Modifying Enzymes

5. Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

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