Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein–Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases
Author:
Affiliation:
1. Drug Design, LEO Pharma Research & Early Development, 2750 Ballerup, Denmark
2. Skin Research, LEO Pharma Research & Early Development, 2750 Ballerup, Denmark
Funder
LEO Pharma A/S
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00422
Reference57 articles.
1. IL-17: prototype member of an emerging cytokine family
2. The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases
3. The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties
4. IL-17 cytokines in immunity and inflammation
5. The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of Psoriasis
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