Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds-Reference-Cited by-同舟云学术

Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds

Published:2024-04-04 Issue:8 Volume:67 Page:6456-6494
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ramos Ashley L.¹^ORCID,Goedken Eric R.²,Frank Kristine E.¹^ORCID,Argiriadi Maria A.²,Bazzaz Sana³,Bian Zhiguo¹,Brown Jesse T. C.¹,Centrella Paolo A.³,Chen Hui-Ju¹,Disch Jeremy S.³^ORCID,Donner Pamela L.¹,Duignan David B.²,Gikunju Diana³,Greszler Stephen N.¹^ORCID,Guié Marie-Aude³,Habeshian Sevan³,Hartl Hajnalka E.³,Hein Christopher D.¹,Hutchins Charles W.¹,Jetson Rachael³,Keefe Anthony D.³,Khan Hasan¹,Li Huan-Qiu¹,Olszewski Allison³,Ortiz Cardona Benjamin J.¹^ORCID,Osuma Augustine¹,Panchal Sanjay C.¹,Phelan Ryan¹^ORCID,Qiu Wei¹,Shotwell J. Brad¹^ORCID,Shrestha Anurupa¹,Srikumaran Myron¹,Su Zhi¹,Sun Chaohong¹,Upadhyay Anup K.¹,Wood Michael D.¹,Wu Haihong¹,Zhang Ruijie¹^ORCID,Zhang Ying³,Zhao Gang¹,Zhu Haizhong¹,Webster Matthew P.¹^ORCID

Affiliation:

1. AbbVie Incorporated, North Chicago, Illinois 60064, United States

2. AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States

3. X-Chem, Waltham, Massachusetts 02453, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02397

Reference35 articles.

1. IL-17 Signaling: The Yin and the Yang

2. The IL-17 Family of Cytokines in Health and Disease

3. The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing

4. Anti IL-17 in psoriasis

5. Anti-IL-17 phase II data for psoriasis: A review

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