Structure-Based Design, Optimization, and Development of [<sup>18</sup>F]LU13: A Novel Radioligand for Cannabinoid Receptor Type 2 Imaging in the Brain with PET-Reference-Cited by-同舟云学术

Structure-Based Design, Optimization, and Development of [¹⁸F]LU13: A Novel Radioligand for Cannabinoid Receptor Type 2 Imaging in the Brain with PET

Published:2022-06-30 Issue:13 Volume:65 Page:9034-9049
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gündel Daniel¹,Deuther-Conrad Winnie¹,Ueberham Lea¹,Kaur Sarandeep¹,Otikova Elina¹,Teodoro Rodrigo¹,Toussaint Magali¹,Lai Thu Hang¹²^ORCID,Clauß Oliver¹^ORCID,Scheunemann Matthias¹,Bormans Guy³^ORCID,Bachmann Michael¹,Kopka Klaus¹⁴,Brust Peter¹⁵^ORCID,Moldovan Rareş-Petru¹^ORCID

Affiliation:

1. Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Research Site Leipzig, 04318 Leipzig, Germany

2. Department of Research and Development, ROTOP Pharmaka GmbH, 01069 Dresden, Germany

3. Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, BE-3000 Leuven, Belgium

4. Faculty of Chemistry and Food Chemistry, School of Science, TU Dresden, 01069 Dresden, Germany

5. The Lübeck Institute of Experimental Dermatology, University Medical Center Schleswig-Holstein, 23562 Lübeck, Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00256

Reference60 articles.

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