Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein–Protein Interaction-Reference-Cited by-同舟云学术

Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein–Protein Interaction

Published:2022-12-09 Issue:24 Volume:65 Page:16818-16828
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pallesen Jakob S.¹^ORCID,Munier Claire C.²^ORCID,Bosica Francesco¹,Andrei Sebastian A.³,Edman Karl⁴,Gunnarsson Anders⁴,La Sala Giuseppina¹^ORCID,Putra Okky Dwichandra⁵^ORCID,Srdanović Sonja⁶,Wilson Andrew J.⁶^ORCID,Wissler Lisa⁴,Ottmann Christian³^ORCID,Perry Matthew W. D.²^ORCID,O’Mahony Gavin¹^ORCID

Affiliation:

1. Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden

2. Medicinal Chemistry, Research and Early Development, Respiratory & Immunology, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden

3. Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Technische Universiteit Eindhoven, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands

4. Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden

5. Early Product Development and Manufacturing, Pharmaceutical Sciences R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden

6. School of Chemistry, Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, West Yorkshire LS2 9JT, U.K.

Funder

AstraZeneca

H2020 Marie Sklodowska-Curie Actions

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01635