N-Biphenyl Pyrrolinones and Dibenzofurans as RNA-Binding Protein LIN28 Inhibitors Disrupting the LIN28–Let-7 Interaction

Author:

Borgelt Lydia123,Hohnen Lisa124,Pallesen Jakob S.5ORCID,Hommen Pascal123,Goebel Georg L.123,Bosica Francesco5,Liu Yang123ORCID,O’Mahony Gavin5ORCID,Wu Peng12ORCID

Affiliation:

1. Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Otto-Hahn Str. 15, Dortmund 44227, Germany

2. Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn Str. 11, Dortmund 44227, Germany

3. Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn Str. 6, Dortmund 44227, Germany

4. Faculty of Chemistry and Biochemistry, Ruhr-University Bochum, Universitätsstr. 150, Bochum 44801, Germany

5. Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, SE-431 83 Mölndal, Sweden

Funder

Merck KGaA

AstraZeneca M?lndal

Pfizer

Max-Planck-Gesellschaft

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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