Design and Evaluation of [<sup>18</sup>F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates-Reference-Cited by-同舟云学术

Design and Evaluation of [¹⁸F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates

Published:2022-12-22 Issue:1 Volume:66 Page:641-656
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Longbin¹^ORCID,Johnson Peter D.²^ORCID,Prime Michael E.²^ORCID,Khetarpal Vinod¹,Brown Christopher J.²,Anzillotti Luca³,Bertoglio Daniele⁴,Chen Xuemei⁵,Coe Samuel²,Davis Randall⁵,Dickie Anthony P.²,Esposito Simone³,Gadouleau Elise²,Giles Paul R.²,Greenaway Catherine²,Haber James⁵,Halldin Christer⁶,Haller Scott⁷,Hayes Sarah²,Herbst Todd¹,Herrmann Frank⁸,Heßmann Manuela⁸,Hsai Ming Min⁵,Khani Yaser⁶,Kotey Adrian²,Lembo Angelo³,Mangette John E.⁵,Marriner Gwendolyn A.⁷,Marston Richard W.²,Mills Matthew R.²,Monteagudo Edith¹,Forsberg-Morén Anton⁶,Nag Sangram⁶^ORCID,Orsatti Laura³^ORCID,Sandiego Christine⁹,Schaertl Sabine⁸,Sproston Joanne²,Staelens Steven⁴,Tookey Jack²,Turner Penelope A.²,Vecchi Andrea³,Veneziano Maria³,Muñoz-Sanjuan Ignacio¹,Bard Jonathan¹^ORCID,Dominguez Celia¹

Affiliation:

1. CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States

2. Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K.

3. Experimental Pharmacology Department, IRBM S.p.A., Via Pontina km 30,600, Pomezia, Roma 00071, Italy

4. Molecular Imaging Center Antwerp (MICA), University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium

5. Curia Global, Inc., 1001 Main Street, Buffalo, New York 14203, United States

6. Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, Stockholm S-17176, Sweden

7. Charles River Laboratories, 54943 North Main Street, Mattawan, Michigan 49071, United States

8. Evotec SE, Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany

9. Invicro, 60 Temple St, Ste 8A, New Haven, Connecticut 06510, United States

Funder

CHDI Foundation

Universiteit Antwerpen

Fonds Wetenschappelijk Onderzoek

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01585

Reference30 articles.

1. Huntington disease

2. Huntingtin localization in brains of normal and Huntington's disease patients

3. Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

4. Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates

5. Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand

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